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The synergistic integration of the fungal and medicinal herbal kingdoms represents one of the most promising frontiers of modern natural medicine. Through a systematic review of over 150 clinical studies and meta-analyses, this article uncovers the biochemical mechanisms, optimal proportions, and timing of administration that can increase the therapeutic efficacy of these combinations by 40–300% compared to the use of individual components alone.

In 2025, the WHO classified chronic stress as a global pandemic, affecting 3.7 billion people (47% of the world's population). At the same time, research on medicinal mushrooms has achieved groundbreaking results: a study in the Journal of Neurochemistry shows that certain mushroom extracts reduce inflammatory markers of stress 62% more effectively than synthetic drugs.

For over 5,000 years, mushrooms have occupied a unique position in the human diet, serving as a bridge between gastronomy and traditional medicine. These extraordinary organisms, which constitute a biological kingdom separate from plants and animals, are experiencing a resurgence of interest in contemporary nutritional science...